FIG 1.

The percentage of individuals predicted to be cured by five DHA-PPQ dosing regimens and one poor-adherence scenario. Cure rates were estimated across seven different PK calibrations for PPQ. The regimens and poor-adherence scenario are described in the text and summarized in Table 1. The PK calibrations are as follows (see the text for more details). Calibration 1 is the one-compartment PK model described in reference 7. Calibrations 2a to 2c are two-compartment models based on data from references 20 to 22, respectively. Calibrations 3a to 3c are three-compartment models based on data from references 14, 23, and 24, respectively.