FIG 3.

Why splitting DHA doses has such a large impact on overall killing. (Top) DHA concentrations following the administration of either the standard daily dose (4 mg/kg) or half that amount, as used in the split doses, i.e., 2 mg/kg. (Middle) How the DHA concentration translates into parasite killing (per hour) when using the standard Michaelis-Menten killing curves (e.g., equation 1 in reference 8) and the DHA parameters given in the text. (Bottom) Posttreatment drug killing (per hour) by DHA, obtained by converting the DHA concentration profiles in the top panel into drug killing rates by using the function in the middle panel.