TABLE 1.
DHA-PPQ dosing regimens and a poor-adherence scenario investigated in this study
| Regimena | Dosing interval | DHA/PPQ amt (mg/kg) |
|
|---|---|---|---|
| Single dose | Total dose | ||
| SR3/3 (standard regimen) | Once daily for 3 days | 4/18 | 12/54 |
| eSTD5/5 (extended regimen) | Once daily for 5 days | 2.4/10.8 | 12/54 |
| pa[eSTD5/5] (eSTD5/5 with poor adherence) | Once daily for 3 days (doses four and five missed) | 2.4/10.8 | 7.2/32.4 |
| eITD5/5 (increased and extended regimen) | Once daily for 5 days | 4/18 | 20/90 |
| sSTD6/3 (split SR3/3) | Twice daily for 3 days | 2/9 | 12/54 |
| sITD6/3 (twice SR3/3) | Twice daily for 3 days | 4/18 | 24/108 |
a
The DHA-PPQ ratio in the combination is 1:4.5, which is the ratio of the target dose recommended by the WHO. For the dosing regimens containing the commercially available fixed-dose combination (1:8 ratio), see Table S2 in the supplemental material.