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Population parameter estimates for subjects receiving tafenoquine for the exposure-response model in the time-to-event analysis
| Parameter | Population meana (% CV) | Hazard ratio (95% CI) |
|---|---|---|
| Base | 1.69 e−09 (43.7) | |
| Shape | 5.06 (4.2) | |
| Delay function | 0.045 (13.3) | |
| Slope (AUC) | −0.0144 (24.4) | 0.698b (0.587, 0.829) |
| Beta (country) | −1.01 (32.9) | 0.36c (0.19, 0.70) |
Precision expressed as percent coefficient of variation.
Twenty-five-unit change in AUC.
Thailand compared to Brazil/Peru.
