TABLE 1.

Antimicrobial susceptibility profiles of S. aureus isolates recovered from households of children with community-onset MRSA infection

Location from which isolate was recovered	No. of S. aureus isolates tested	% susceptiblea										% MDR4d
		METb	CLIc	ERY	SXT	RIF	TET	CIP	LZD	CPT	MUP
Overall	1,633	45	90	47	100	100	98	68	100	100	96	4
People	770	42	90	44	100	100	98	65	100	100	96	4
Index patient	263	26	91	34	100	100	99	58	100	100	95	5
Infection	110e	0f	94	17	100	100	99	42	100	100	98	9
Colonization	153	44	89	46	100	100	99	67	100	100	94	3
Anterior nares	61	48	89	53	100	100	100	67	100	100	97	3
Axillae	31	42	90	48	100	100	100	61	100	100	87	0
Inguinal folds	61	41	89	39	100	100	98	69	100	100	95	3
Household contact colonizationg	507	50	89	49	100	100	98	68	100	100	96	4
Anterior nares	228	55	90	52	100	100	99	69	100	100	97	4
Axillae	110	44	90	46	100	100	99	69	100	100	95	5
Inguinal folds	169	47	88	47	100	100	96	67	100	100	95	4
Adult household contact colonization	278	49	88	45	100	100	97	67	100	100	95	4
Anterior nares	120	56	88	48	100	100	98	69	100	100	96	3
Axillae	62	42	90	40	100	100	98	69	100	100	95	3
Inguinal folds	96	46	85	44	100	100	95	63	100	100	93	5
Child household contact colonization	229	51	91	55	100	100	99	69	100	100	97	4
Anterior nares	108	55	91	57	100	100	99	69	100	100	99	5
Axillae	48	46	90	52	100	100	100	67	100	100	94	6
Inguinal folds	73	48	92	52	100	100	99	73	100	100	97	3
Pets	48	38	85	48	100	100	100	69	100	100	96	8
Dog	39	41	87	56	100	100	100	74	100	100	100	8
Anterior nares	16	38	88	69	100	100	100	81	100	100	100	6
Dorsal fur	23	44	87	48	100	100	100	70	100	100	100	9
Cat	9	22	78	11	100	100	100	44	100	100	78	11
Anterior nares	4	25	75	25	100	100	100	25	100	100	75	25
Dorsal fur	5	20	80	0	100	100	100	60	100	100	80	0
Environment	815	48	90	50	100	100	98	71	100	100	97	3
Living room	166	44	88	52	100	100	99	69	100	100	97	4
TV remote control	52	42	90	44	100	100	98	67	100	100	96	4
Telephone	36	36	92	53	100	100	100	71	100	100	97	0
Computer keyboard and mouse	37	51	87	62	100	100	100	73	100	100	97	5
Video game controller	41	46	83	54	100	100	98	66	100	100	98	5
Bathroom	404	50	90	49	100	100	98	72	100	100	98	2
Sink faucet handle	43	49	86	49	100	100	98	67	100	100	98	5
Hand towel	22	32	86	41	100	100	100	62	100	100	96	5
Index bath towel	27	63	93	59	100	100	100	78	100	100	100	0
Toilet handle	33	58	88	55	100	100	94	79	100	100	100	0
Door handle	32	47	91	41	100	100	100	63	100	100	97	0
Light switch	39	49	92	49	100	100	100	64	100	100	100	5
Sink	52	48	94	54	100	100	100	75	100	100	98	0
Bathtub or shower	44	50	89	46	100	100	96	82	100	100	98	2
Soap bar or dish in bathtub or shower	17	29	82	29	100	100	88	65	100	100	100	6
Toilet seat	47	60	89	55	100	100	98	81	100	100	100	0
Countertop	48	48	92	46	100	100	96	70	100	100	96	2
Kitchen	190	49	91	52	100	100	99	71	100	100	95	3
Hand towel	22	55	91	50	100	100	100	68	100	100	96	0
Sink faucet handle	35	46	97	60	100	100	100	66	100	100	94	3
Sponge/cloth	32	47	94	59	100	100	100	75	100	100	94	3
Refrigerator door handle	55	47	86	49	100	100	100	71	100	100	95	6
Kitchen table	46	52	91	44	100	100	98	74	100	100	96	0
Bedroom	55	40	89	46	100	100	98	64	100	100	95	4
Bed sheets and pillowcase	55	40	89	46	100	100	98	64	100	100	95	4

^aMET, methicillin; CLI, clindamycin; ERY, erythromycin; SXT, trimethoprim-sulfamethoxazole; RIF, rifampin; TET, tetracycline; CIP, ciprofloxacin; LZD, linezolid; CPT, ceftaroline; MUP, mupirocin.

^bAs predicted by cefoxitin testing.

^cClindamycin-susceptible isolates exhibiting inducible clindamycin resistance (n = 144) were considered clindamycin resistant.

^dMultidrug resistance (MDR4) here was defined as β-lactam resistance plus resistance to three additional systemic antimicrobial drug classes (i.e., excluding mupirocin).

^eSome infection isolates were unable to be obtained by the study team and are thus missing various susceptibility data; therefore, % susceptibility is out of <110 for RIF (n = 84), CIP (n = 85), LZD (n = 76), CPT (n = 64), and MUP (n = 64).

^fStudy entry criteria specified a MRSA infection.

^gDoes not include the isolates recovered from index patients.