TABLE 1.

Amino acid variations in the sequences of PDC enzymes

Strain(s)	PDC	Residue at amino acid position showna
		1	19	29	71	79	100	121	129	150	154	175	179	213	216	221	223	290	291	292	293	294	295	330	347	365
Wild-type AmpC producers
PAO1b	PDC-1	G	V	A	A	T	R	F	Q	L	P	M	V	V	G	E	Y	T	P	M	A	L	Q	V	N	G
14.2028	PDC-3					A
13.1642	PDC-8					A				R
13.1781	PDC-24					A																				A
PA14b	PDC-34	D		T		A			R				L													A
11.773	PDC-35	D			V	A							L													A
ESAC producers
12.1227 and 12.1255	PDC-44					A																P
10.257	PDC-50					A								A
12.1285	PDC-73					A					L
12.1111 and 13.1716	PDC-74					A									R
12.1129 and 13.1727	PDC-75					A									R									I
13.1415	PDC-76					A																			I
13.1404, 13.1696, and 13.1760	PDC-77														R
11.571	PDC-78						H								R
11.516	PDC-79															K
13.1737	PDC-80															G
13.1514	PDC-81					A					L															A
13.1770	PDC-82					A		L				L														A
4836	PDC-83		A			A								A												A
13.1482	PDC-84		A			A								A											I	A
12.961	PDC-85					A											H									A
13.1755 and 14.1999	PDC-86	D				A							L			K								I		A
11.698 and 13.1775	PDC-87	D				A							L											I	I	A
13.1601	PDC-88	D				A							L					Δ	Δ					I		A
09.236	PDC-89	D				A							L					Δ	Δ	Δ						A
13.1562	PDC-90	D				A							L					Δ	Δ	Δ				I		A
11.813	PDC-91	D				A							L					Δ	Δ	Δ	Δ			I		A
12.1121 and 13.1389	PDC-92	D				A							L									Δ	Δ			A
14.2036	PDC-93	D				A							L									P				A

^aThe numbering of the amino acids refers to the mature protein from strain PAO1, after cleavage of the 26 N-terminal amino acid residues of the signal peptide. Variations highlighted in boldface are considered common polymorphisms. The role of V19A has not been investigated specifically in this study.

^bReference strain of P. aeruginosa (http://v2.pseudomonas.com).