Interaction between A77/V77 and other residues in the adjacent helixes of CTX-M-15 and CTX-M-55. (A) A77 in CTX-M-15 interacting with residues L81, L127, L138, and W210: the distances between A77 and L81, L127, L138, and W210 were 5.3 Å, 3.8 Å, 4.2 Å, and 4.9 Å, respectively; (B) V77 in CTX-M-15 interacting with residues L81, L127, L138, and W210: the distances between V77 and L81, L127, L138, and W210 were 4.2 Å, 3.6 Å, 3.2 Å, and 3.4 Å, respectively.