TABLE 3.
Sequences and homologies among the studied insect-derived PrAMPs
| Peptide | Sequencea | Activity loss in ΔsbmA mutants |
|---|---|---|
| Onc18 | VDKP- PYLPRPRPPR RIYNR | 4× |
| Onc72 | ..... .......... O...O | 8× |
| Onc112 | ..... .......... r...r | 4× |
| Chex1-Arg20 | ch-RP...R .......... PVR | 4× |
| Pyrrhocoricin | ...G. S.....T... P....N | Resistantb |
| Drosocin | G..R ..S.. .TSHP .PIRV | Resistant |
| Api88/137 | Gu-ONNRP V.I.. ....H PRL | Resistant |
a
ch, O, r, and gu denote 1-amino cyclohexyl carboxylic acid, l-ornithin, d-arginine, and N,N,N′,N′-tetramethylguanidino, respectively. Dots indicate amino acids identical to the sequence of Onc18. Homologous sequences important for the bacterial uptake are underlined.
b
MIC, ≥128 μg/ml.