TABLE 4.

TAF antiviral activities in combination with other antiretroviral drugs

Drug combination	Class	Net effect	Synergy scorea	Antagonism scorea
TAF + TFV	NRTI	Additive	24	−14
TAF + FTC	NRTI	Strong synergy	131	−9
TAF + EFV	NNRTI	Moderate synergy	100	−7
TAF + NVP	NNRTI	Slight synergy	41	−14
TAF + EVG	INSTI	Strong synergy	271	−9
TAF + RAL	INSTI	Strong synergy	205	−10
TAF + DTG	INSTI	Strong synergy	179	−10
TAF + ATV	PI	Moderate synergy	96	−10
TAF + DRV	PI	Moderate synergy	56	−12
TAF + COBI	PK enhancer	Additive	17	−22
TAF + TAF	Control	Additive	20	−17
ddI + RBV	Control	Strong synergy	302	−20
d4T+ RBV	Control	Strong antagonism	20	−340

^aThe data shown represent the means of the results of >3 independent experiments performed in triplicate.