TABLE 1.
Species | Country of origin | CBS no./source | GenBank accession no. | MIC/MEC (μg/ml) ofa: |
|||||||
---|---|---|---|---|---|---|---|---|---|---|---|
AMB | ISA | POS | ITC | VRC | FLU | CASb | MFGb | ||||
E. rostratum (E. mcginnisii) | USA | CBS 120308/clinical | KT265236 | 0.125 | 2 | 0.063 | 0.25 | 0.5 | 32 | 1 | 0.125 |
CBS 325.87T/clinical | KT265237 | 0.25 | 4 | 0.125 | 0.25 | 1 | 16 | 2 | 0.5 | ||
E. rostratum | Canada | CBS 112815/clinical | KT265238 | 1 | 1 | 0.125 | 0.5 | 1 | >64 | 4 | 8 |
CBS 128063/clinical | KT265239 | 0.25 | 8 | 0.25 | 0.5 | 2 | 32 | 1 | <0.008 | ||
CBS 128061/clinical | KT265240 | 0.063 | 1 | 0.125 | 0.125 | 0.5 | 32 | 0.5 | <0.008 | ||
CBS 128060/clinical | KT265245 | 0.125 | 2 | 0.125 | 0.25 | 1 | 8 | 0.5 | 0.25 | ||
CBS 131565/clinical | KT265242 | 0.25 | 4 | 0.125 | 0.25 | 1 | 16 | 1 | 0.125 | ||
CBS 128062/clinical | KT265247 | 0.5 | 4 | 0.25 | 0.5 | 2 | 32 | 2 | 0.25 | ||
India | CBS 134641/clinical | KT265248 | 0.5 | 8 | 0.25 | 0.5 | 2 | 32 | 0.5 | 0.25 | |
CBS 134640/clinical | KT265241 | 0.125 | 4 | 0.5 | 0.25 | 2 | 32 | 1 | 0.25 | ||
E. gedarefense | Sudan | CBS 504.90/environment | KT265243 | 0.25 | 1 | 0.063 | 0.063 | 1 | 8 | 1 | 0.5 |
CBS 297.80T/environment | KT265244 | 0.25 | 1 | 0.125 | 0.5 | 2 | 16 | 1 | 0.063 | ||
E. neoregeliae IM201-D | Japan | CBS 132832T/environment | KT265254 | 0.25 | 2 | 0.125 | 0.25 | 1 | 16 | 1 | 0.125 |
E. neoregeliae IM201-E | CBS 132833/environment | KT265255 | 0.125 | 2 | 0.125 | 0.125 | 0.5 | 32 | 1 | 0.063 | |
E. pedicellatum | USA | CBS 322.64/environment | KT265258 | 0.25 | 0.5 | 0.125 | 0.063 | 0.25 | 1 | 1 | 0.25 |
Turkey | CBS 375.76/environment | KT265259 | 0.5 | 0.25 | 0.125 | 0.25 | 0.5 | 2 | 0.5 | 0.125 | |
E. protrudens | Australia | CBS 132710T/environment | KT265256 | 0.125 | 2 | 0.5 | 0.25 | 2 | 8 | 2 | 0.5 |
E. fusiforme | CBS 132709T/environment | KT265257 | 0.031 | 0.125 | 0.031 | 0.031 | 0.063 | 1 | 1 | 0.25 | |
E. antillanum | Cuba | CBS 412.93T/environment | KT265246 | 1 | 4 | 0.25 | 0.25 | 2 | >64 | 4 | 8 |
E. curvatum | Venezuela | CBS 505.90T/environment | KT265252 | 0.25 | 2 | 1 | >16 | 2 | 32 | 1 | 2 |
E. prolatum | Unknown | CBS 128058/unknown | KT265249 | 1 | 1 | 0.125 | 0.25 | 0.5 | >64 | 2 | 4 |
Unknown | CBS 128059/unknown | KT265250 | 0.25 | 1 | 0.25 | 0.5 | 1 | 8 | 4 | 1 | |
E. holmii | Unknown | CBS 128053/unknown | KT265253 | 0.25 | 1 | 1 | >16 | 1 | 64 | 1 | 0.125 |
Exserohilum sp. | Unknown | CBS 128064/unknown | KT265251 | 0.25 | 8 | 2 | >16 | 4 | >64 | 1 | 0.125 |
AMB, amphotericin B; ISA, isavuconazole; POS, posaconazole; ITC, itraconazole; VRC, voriconazole; FLU, fluconazole; CAS, caspofungin; MFG, micafungin.
For echinocandins, MECs were defined as lowest drug concentrations that allowed the growth of small, rounded, and degenerated hyphae vis-à-vis the growth in the control well.