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. 2015 Sep 18;59(10):6642–6645. doi: 10.1128/AAC.01218-15

TABLE 1.

Origin, source, and MIC/MEC data of all Exserohilum isolates tested

Species Country of origin CBS no./source GenBank accession no. MIC/MEC (μg/ml) ofa:
AMB ISA POS ITC VRC FLU CASb MFGb
E. rostratum (E. mcginnisii) USA CBS 120308/clinical KT265236 0.125 2 0.063 0.25 0.5 32 1 0.125
CBS 325.87T/clinical KT265237 0.25 4 0.125 0.25 1 16 2 0.5
E. rostratum Canada CBS 112815/clinical KT265238 1 1 0.125 0.5 1 >64 4 8
CBS 128063/clinical KT265239 0.25 8 0.25 0.5 2 32 1 <0.008
CBS 128061/clinical KT265240 0.063 1 0.125 0.125 0.5 32 0.5 <0.008
CBS 128060/clinical KT265245 0.125 2 0.125 0.25 1 8 0.5 0.25
CBS 131565/clinical KT265242 0.25 4 0.125 0.25 1 16 1 0.125
CBS 128062/clinical KT265247 0.5 4 0.25 0.5 2 32 2 0.25
India CBS 134641/clinical KT265248 0.5 8 0.25 0.5 2 32 0.5 0.25
CBS 134640/clinical KT265241 0.125 4 0.5 0.25 2 32 1 0.25
E. gedarefense Sudan CBS 504.90/environment KT265243 0.25 1 0.063 0.063 1 8 1 0.5
CBS 297.80T/environment KT265244 0.25 1 0.125 0.5 2 16 1 0.063
E. neoregeliae IM201-D Japan CBS 132832T/environment KT265254 0.25 2 0.125 0.25 1 16 1 0.125
E. neoregeliae IM201-E CBS 132833/environment KT265255 0.125 2 0.125 0.125 0.5 32 1 0.063
E. pedicellatum USA CBS 322.64/environment KT265258 0.25 0.5 0.125 0.063 0.25 1 1 0.25
Turkey CBS 375.76/environment KT265259 0.5 0.25 0.125 0.25 0.5 2 0.5 0.125
E. protrudens Australia CBS 132710T/environment KT265256 0.125 2 0.5 0.25 2 8 2 0.5
E. fusiforme CBS 132709T/environment KT265257 0.031 0.125 0.031 0.031 0.063 1 1 0.25
E. antillanum Cuba CBS 412.93T/environment KT265246 1 4 0.25 0.25 2 >64 4 8
E. curvatum Venezuela CBS 505.90T/environment KT265252 0.25 2 1 >16 2 32 1 2
E. prolatum Unknown CBS 128058/unknown KT265249 1 1 0.125 0.25 0.5 >64 2 4
Unknown CBS 128059/unknown KT265250 0.25 1 0.25 0.5 1 8 4 1
E. holmii Unknown CBS 128053/unknown KT265253 0.25 1 1 >16 1 64 1 0.125
Exserohilum sp. Unknown CBS 128064/unknown KT265251 0.25 8 2 >16 4 >64 1 0.125
a

AMB, amphotericin B; ISA, isavuconazole; POS, posaconazole; ITC, itraconazole; VRC, voriconazole; FLU, fluconazole; CAS, caspofungin; MFG, micafungin.

b

For echinocandins, MECs were defined as lowest drug concentrations that allowed the growth of small, rounded, and degenerated hyphae vis-à-vis the growth in the control well.