TABLE 1.
Antibiotic susceptibilities of P. mirabilis PM58, its transconjugant PM58-J53, and recipient strain E. coli J53
| Antimicrobial category | Antimicrobial agent | MIC (μg/ml) |
||
|---|---|---|---|---|
| PM58 | PM58-J53 | E. coli J53 | ||
| Penicillins | Ampicillin | >256 | >256 | 8 |
| Penicillins + β-lactamase inhibitors | Ampicillin-sulbactam | >256 | >256 | 8 |
| Antipseudomonal penicillins + β-lactamase inhibitors | Piperacillin-tazobactam | >256 | >256 | 2 |
| Non-extended-spectrum cephalosporins | Cefazolin | >256 | >256 | 2 |
| Extended-spectrum cephalosporins | Ceftazidime | >256 | >256 | 0.5 |
| Cefepime | >256 | >256 | 0.25 | |
| Cephamycins | Cefotetan | >256 | >256 | 1 |
| Carbapenems | Imipenem | >64 | >64 | <0.125 |
| Meropenem | 8 | 8 | <0.125 | |
| Monobactams | Aztreonam | 1 | 1 | <0.125 |
| Fluoroquinolones | Levofloxacin | 32 | 8 | <0.125 |
| Aminoglycosides | Gentamicin | >64 | >64 | 1 |
| Amikacin | >64 | >64 | 1 | |
| Folate pathway inhibitors | Trimethoprim-sulfamethoxazole | >32 | >32 | 1 |
| Phenicols | Chloroamphenicol | >64 | >64 | 4 |
| Phosphonic acids | Fosfomycin | >1,024 | >1,024 | 2 |
| Tetracyclines | Doxycycline | 128 | 64 | 2 |
| Tetracycline | NDa | >64 | 2 | |
| Glycylcyclines | Tigecycline | NDa | 0.5 | 0.25 |
| Polymyxins | Colistin | NDa | 1 | 0.5 |
a
ND, not determined: P. mirabilis is intrinsically resistant to tetracycline, tigecycline and colistin.