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Genotype specificity of GSK8853
| Genotype | EC50 (nM) | Fold shift | 95% confidence interval (nM) |
|---|---|---|---|
| 1a | 0.5 | 1 | 0.4–0.6 |
| 1b | 1.6 | 3 | 1.3–2.0 |
| 2a | 83,000 | 166,600 | |
| 2b | 2,400 | 4,800 | 1,404–4,431 |
| 3a | 31.4 | 63 | 19.4–52.1 |
| 4a | 2.4 | 5 | 1.3–4.6 |
| 5a | 2.3 | 5 | 1.8–2.9 |
| 6a (75–130)a | 6,300 | 12,600 | 5,483–7,503 |
| 6o (75–130)a | >50,000 | >100,000 |
Chimeras containing full NS4B genotype 6a and 6o replacements were not viable, so analysis was performed with replicons containing the genotype 6 NS4B sequences from residues 75 to 130.
