FIG 5.

Ultrathin sections of L. amazonensis promastigotes in the control group (A) or in groups treated with E5700, ITZ, or POSA (B to F) for 48 h. (B) Result with 1 μM POSA; (C) 1 μM ITZ; (D to F) 30 nM E5700. Several alterations were observed, such as the presence of several lipid bodies (asterisks), which sometimes appeared near the endoplasmic reticulum and mitochondrion profiles (C and E), and intense disorganization and swelling of the mitochondrion (B, D, and F). N, nucleus; m, mitochondrion; k, kinetoplast.