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Bactericidal efficacy of tobramycin against P. aeruginosa biofilmsa
| Strain | MBEC [μg/ml (μmol/ml)] |
|
|---|---|---|
| Aerobic exposure | Anaerobic exposure | |
| Nonmucoid | 200 (0.43) | 1,600 (3.42) |
| Mucoid | 800 (1.71) | 1,600 (3.42) |
Biofilms were exposed to tobramycin in PBS (pH 6.5) for 18 h under aerobic or anaerobic conditions. The MBEC18 h is reported as the concentration of COS-NO required for 5-log-unit reduction in biofilm viability.
