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Increased sensitivity of DPB 636 to ciprofloxacin can be reversed by expression of recombinant E. coli topoisomerase I but not by recombinant M. tuberculosis topoisomerase I. Tenfold serial dilutions of DPB635 (topA+) and DPB636 (topA66) transformed with pBAD/Thio vector or pETOP- or pMTOP-expressing recombinant E. coli and M. tuberculosis topoisomerase I were spotted on control plates with or without ciprofloxacin.
