TABLE 1.

Top 10 templates used by I-TASSER^a

Rank	PDB hit	Ident1	Ident2	Cov.	Norm. Z-score
1	4pypA	0.28	0.26	0.87	3.85
2	4gbyA	0.26	0.26	0.88	5.79
3	4pypA	0.27	0.26	0.87	5.39
4	4gc0A	0.25	0.26	0.88	3.91
5	4gc0A	0.26	0.26	0.89	3.65
6	4pypA	0.28	0.26	0.87	5.35
7	4gc0A	0.26	0.26	0.89	4.83
8	4pypA	0.29	0.26	0.87	6.61
9	4pypA	0.28	0.26	0.87	4.68
10	4pypA	0.28	0.26	0.87	4.82

^aRank of templates represents the top 10 threading templates used by I-TASSER; PDB hit, Protein Data Bank template hit; Ident1 is the percent sequence identity of the templates in the threading aligned region with the query sequence; Ident2 is the percent sequence identity of the whole template chains with the query sequence; Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein; Norm. Z-score is the normalized Z-score of the threading alignments; alignment with a normalized Z-score of >1 means a good alignment and vice versa.