FIG 1.

Single-dose serum pharmacokinetics of TXA-707 in neutropenic mice. Three different doses of prodrug TXA-709 that differed in concentration by 4-fold on a milligram-per-kilogram basis were administered by the oral route. Serum drug concentrations of active metabolite TXA-707 were measured by the use of LC-MS/MS. Groups of three mice were sampled for each time point. Samples were collected at 1, 2, 4, 6, 12, and 24 h after administration. Each symbol represents the mean value of data from three animals. The error bars represent the standard deviations. The maximum serum concentration (Cmax), the area under the drug concentration curve from h 0 to infinity (AUC), and the elimination half-life (T1/2) are shown for each dose.