FIG 5.

In vivo dose effect of TXA-709 against five selected S. aureus isolates using a neutropenic mouse thigh model. Each symbol represents the mean of data from four thighs. Six total drug dose levels were fractionated into a regimen of administration every 6 h. The TXA-709 exposure is expressed as the total drug 24-h AUC/MIC ratio. The burden of organisms was measured at the start and end of therapy. The study period was 24 h. The horizontal line at 0 represents the burden of organisms in the thighs of mice at the start of therapy. Data points below the line represent killing, and points above the line represent growth. The R² data represent the coefficient of determination. The ED₅₀ data represent the AUC/MIC ratios associated with 50% of the maximal effect (Emax), and N is the slope of the relationship or the Hill coefficient. The line drawn through the data points is the best-fit line based on the sigmoid Emax formula.