TABLE 2.
In vitro and in vivo efficacy of TXA-707 against selected S. aureus isolates using the 24-h AUC/MIC ratio as a predictive pharmacodynamic indexa
| Isolate or parameter | TXA-707 MIC (mg/liter) | 24-h static dose (mg/kg) | 24-h static-dose tAUC/MIC | 24-h static-dose fAUC/MIC | 24-h 1-log kill dose (mg/kg) | 24-h 1-log kill tAUC/MIC | 24-h 1-log kill fAUC/MIC |
|---|---|---|---|---|---|---|---|
| Isolates | |||||||
| ATCC 25923 | 1 | 186.1 | 111.7 | 15.6 | 436.5 | 222.3 | 31.1 |
| 307109 | 1 | 157.5 | 98.3 | 13.8 | 325.5 | 173.3 | 24.3 |
| R2527 | 1 | 235.6 | 133.5 | 18.7 | 527.3 | 262.4 | 36.7 |
| ATCC 33591 | 1 | 222.7 | 127.9 | 17.9 | NA | ||
| MW2 | 1 | 247.0 | 138.6 | 19.4 | 640.0 | 312.2 | 43.7 |
| Parameters | |||||||
| Mean | 1 | 209.8 | 122.0 | 17.1 | 482.3 | 242.6 | 34.0 |
| Median | 1 | 222.7 | 127.9 | 17.9 | 481.9 | 242.4 | 33.9 |
| SD | 0 | 37.1 | 16.7 | 2.3 | 133.6 | 59.0 | 8.3 |
a
tAUC, AUC for total drug (free and protein bound), fAUC, AUC for unbound fraction (not protein bound); NA, not achieved.