Skip to main content
. 2015 Sep 18;59(10):6296–6307. doi: 10.1128/AAC.00640-15

FIG 2.

FIG 2

Sterol biosynthesis pathway after inhibition of sterol C14-demethylase (encoded by ERG11). Enzyme A, sterol C14-demethylase (ERG11); enzyme B, sterol C24-methyltransferase (ERG6); enzyme C, sterol C4-demethylase (ERG25, ERG26, and ERG27); enzyme D, sterol C5-desaturase (ERG3); enzyme E, sterol Δ8(7)-isomerase (ERG2); enzyme F, sterol C22-desaturase (ERG5); enzyme G, Δ24(28)-reductase (ERG4). Compound 1, lanosta-8,24-dien-3β-ol (lanosterol); compound 2, 4,4,14-trimethylergosta-8,24(28)-dien-3β-ol (eburicol); compound 3, 14-methylergosta-8,24(28)-dien-3β-ol (14-methylfecosterol); compound 4, 14-methylergosta-8,24(28)-dien-3β,6α-diol; compound 5, 14-methylergosta-7,24(28)-dien-3β,6α-diol; compound 6, 14-methylergosta-8,22,24(28)-trien-3β,6α-diol; compound 7, 14-methylergosta-8,22-dien-3β,6α-diol; compound 8, 14-methylergosta-8-en-3β,6α-diol; compound 9, 14-methylergosta-7,22,24(28)-trien-3β,6α-diol; compound 10, 14-methylergosta-7-en-3β,6α-diol; compound 11, 14-methylergosta-7,22-dien-3β,6α-diol; compound 12, 4,4-dimethylergosta-8,14,24-trien-3β-ol (follicular fluid-meiosis-activating sterol [FF-MAS]); compound 13, ergosta-5,7,22-trien-3β-ol (ergosterol); compound 14, 4,4,14-trimethylergosta-8,22,24(28)-trien-3β-ol; compound 15, 4,4,14-trimethylergosta-8,22-dien-3β-ol; compound 16, 4,4,14-trimethylergosta-7,22-dien-3β-ol; compound 17, 4,4,14-trimethylergosta-8-en-3β-ol. Sterol structures shown in blue, structures detected in this study; sterol structures shown in black, structures postulated but not detected. Red arrow, inhibition of ERG11 caused by EMC120B.