TABLE 4.

Effects of BKI-1294 treatments on cerebral N. caninum Nc-Liv infection in nonpregnant mice, dams, and pups^a

Parameter	BKI-1294	Placebo control
Nonpregnant females (no./total no.)
Total no.	6	6
Seropositive	6/6	6/6
N. caninum positive	1/6b	6/6
Dams and pups (no./total no.)
Total no. of dams	6	6
Seropositive dams	6/6	6/6
N. caninum-positive dams	1/6b	6/6
Total no. of pups	27	39
N. caninum-positive pups	0/27c	21/39
Stillborn pups	6/27d	8/39

^aMice were treated with BKI-1294 in CMC or with CMC alone as a placebo control, infected with Nc-Liv, and sacrificed as described in Materials and Methods. Adults and pups were tested for the presence of N. caninum in their brains with a specific real-time PCR. Respective numbers of animals in control and 1294-treated groups were compared by chi-square tests.

^bP < 0.005.

^cP < 0.001.

^dP > 0.1.