TABLE 1.
Baseline characteristics according to benznidazole manufacturer
| Characteristic | Benznidazole manufacturer |
P | |
|---|---|---|---|
| Roche (n = 264) | ELEA (n = 208) | ||
| Mean patient age in yr (IQR) | 36 (31–44) | 37 (32–45) | >0.05 |
| No. (%) female | 139 (52) | 111 (53) | >0.05 |
| No. (%) of patients with clinical involvement | >0.05 | ||
| Digestive form | 50 (18.9) | 30 (14.4) | |
| Cardiac forma | 38 (14.4) | 17 (8.2) | |
| Kuschnir 1 | 35 (13.2) | 15 (7.2) | |
| Kuschnir 2 | 3 (1.1) | 2 (0.9) | |
| Median baseline laboratory values (IQR) | >0.05 | ||
| Leukocytes (cells/μl) | 6,050 (5,175–7,200) | 6,100 (5,400–7,375) | |
| Neutrophils (cells/μl) | 3,400 (2,800–4,200) | 3,400 (2,700–4,300) | |
| Eosinophils (cells/μl) | 100 (100–300) | 200 (100–375) | |
| Platelets (cells [10–E9]/liter) | 244 (205–285) | 243 (212–275) | |
| Alanine aminotransferase (IU/liter) | 21 (18–27) | 22 (19–28) | |
| Aspartate aminotransferase (IU/liter) | 19 (14–27) | 19 (14–29) | |
| Alkaline phosphatase (IU/liter) | 78 (63–93) | 83 (71–105) | |
| Gamma glutamyltransferase (IU/liter) | 20 (816–30) | 20 (16–35) | |
a
The Kuschnir scale measures clinical cardiac involvement in Chagas disease. A score of 0 indicates reactive serum and a normal electrocardiogram and chest radiograph; a score of 1 indicates reactive serum, an abnormal electrocardiogram, and a normal chest radiograph; a score of 2 indicates reactive serum, a chest radiograph showing cardiac enlargement, and no radiologic or clinical signs of heart failure; a score of 3 indicates heart failure.