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Pharmacokinetic parameters assessed for ceragenin CSA-13
| Pharmacokinetic parametera | CSA-13 result |
|---|---|
| Cmax (μg/ml) | 5 |
| Tmax (h) | 0.5 |
| t1/2 (h) | 2.95 |
| AUCtotal (μg/ml · h) | 20.46 |
| AUC/MIC ratio | 6.66 |
| MRT (h) | 1.7 |
| CL (ml/h) | 4.88 |
| Protein binding (%) | 99 |
Cmax, maximum plasma concentration; Tmax, time to reach Cmax; t1/2, biological half-life; AUCtotal, total area under the concentration-time curve; MRT, mean residence time; CL, clearance.
