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Characterization of novel NS3 R155 and D168 variants derived from isolates from patients in phase 2 studies
| GTa | NS3 variant | No. of samples | Mean (range) faldaprevir EC50b fold change relative to baseline |
|---|---|---|---|
| 1a | R155K + D168E | 3 | 623 (588–680) |
| D168E | 1 | 24 | |
| D168A | 1 | 360 | |
| R155S | 1 | 131 | |
| 1b | R155Q + D168N | 1 | 162 |
| R155Q + D168V | 1 | 38 | |
| D168Y | 1 | 1,261 |
GT, genotype.
EC50, 50% effective concentration.
