Figure 3.

Carotid intima-media thickness is a marker of early atherogenesis in children with familial hypercholesterolaemia. (A) Increased carotid intima-media thickness is already evident at age 7 years in familial hypercholesterolaemia children. Data from Kusters et al.³³ After 10 years treatment with a statin, while mean carotid intima-media thickness is higher in familial hypercholesterolaemia children than their unaffected siblings (B), there is no significant difference between the two groups in carotid intima-media thickness progression over this period (C). Data from Kusters et al.⁹⁸ Data in (B) and (C) are given as mean ± SEM and are adjusted for age, gender, blood pressure, body mass index, smoking, and family relations. cIMT, carotid intima-media thickness; FH, familial hypercholesterolaemia; NS, not significant.