Table 1.

Characteristics of studies included in this meta-analysis.

Author	Year	Ethnicity	Source of controls	Adjustment for smoking			Case				Control		HWE(P)
					Total	105Ile/Ile	105Ile/Val	105Val/Val	Total	105Ile/Ile	105Ile/Val	105Val/Val
Harries et al.	1997	Caucasian	Healthy controls	No	79	34	35	10	155	79	66	10	0.4396
Ishii et al.	1999	Asian	Healthy controls	Yes	53	42	11	0	50	26	22	2	0.3104
Lu et al.	2002	Asian	Healthy controls	Yes	97	70	22	5	67	41	24	2	0.4940
Yim et al.	2002	Asian	Checkup	No	89	63	24	2	94	57	35	2	0.1995
Zhang et al.	2003	Asian	Healthy controls	Yes	57	47	5	5	48	44	3	1	0.0110
Cheng et al.	2004	Asian	Checkup	Yes	184	97	78	9	212	99	98	15	0.1591
Gaspa et al.	2004	Caucasian	Checkup	No	75	35	35	5	90	47	36	7	0.9767
Xiao et al.	2004	Asian	Healthy controls	Yes	100	70	29	1	100	57	40	3	0.1959
Hu et al.	2005	Asian	Healthy controls	Yes	50	45	3	2	68	59	5	4	0.0000
Rodriguez et al.	2005	Caucasian	Checkup	No	98	52	36	10	198	97	88	13	0.2372
Calikoglu et al.	2006	Caucasian	Healthy controls	Yes	144	88	42	14	150	57	57	36	0.0059
Fang et al.	2006	Asian	Healthy controls	No	87	65	18	4	91	74	16	1	0.8972
Vibhuti et al.	2007	Asian	Healthy controls	Yes	202	105	75	22	136	90	42	4	0.7336
Yeung et al.	2007	Asian	Healthy controls	Yes	163	112	43	8	161	112	47	2	0.2280
Lakhdar et al.	2010	Caucasian	Healthy controls	Yes	234	81	104	49	182	84	79	19	0.9468
Wu et al.	2014	Asian	Healthy controls	Yes	150	113	18	19	150	132	11	7	0.0000
Zuntar et al.	2014	Caucasian	Healthy controls	No	30	10	16	4	60	34	25	1	0.1314