Fig. 4.

ROS-induced modification of the UPS. Red arrows suggest decreased activity of the proteasomal degradation upon induced modification, while blue arrows suggest that modification has opposite effects. On the other side, arrows that points ‘phosphorylation’ to the target proteasomal components are black because the effects of these modification is still experimentally unconfirmed, in the oxidative stress conditions. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)