Figure 1.

(A) Intraplantar injection of AG490 dose-dependently increases the paw withdrawal response (PWL) to a thermal stimulus and (B) paw withdrawal threshold (PWT) to a mechanical stimulus. The thermal hyperalgesia data are presented as a mean percentage of maximal possible effect (% MPE) ± standard error of the mean (SEM). Mechanical hyperalgesia data are expressed by ∆PWT ± SEM. *P<0.05 vs. control; **P<0.001 vs. control. *Indicates significant difference and n.s. represents not significant.