Table 6.
Performance of LBCRS total scores and individual questions across different dementia etiologies
| LBCRS total scores | AD n = 100 | LBD n = 53 | VaD n = 5 | FTD n = 10 | Other n = 9 | P value |
|---|---|---|---|---|---|---|
| Age, y | 79.8 (7.5) | 78.4 (7.7) | 77.2 (6.2) | 72.7 (8.2) | 70.2 (7.5) | .001 |
| Education, y | 15.2 (2.9) | 14.5 (3.6) | 14.8 (3.4) | 16.8 (3.3) | 16.9 (3.4) | .28 |
| Gender, % female | 58.7 | 38.9 | 100.0 | 30.0 | 55.6 | .02 |
| CDR | 1.0 (0.6) | 1.5 (0.9) | 1.7 (0.9) | 0.8 (0.8) | 1.0 (0.8) | <.001 |
| CDR-SB | 5.7 (3.3) | 8.8 (5.2) | 9.3 (6.3) | 5.2 (4.7) | 5.0 (4.4) | <.001 |
| Charlson comorbidity | 2.3 (1.3) | 2.4 (1.5) | 2.6 (1.1) | 2.0 (1.3) | 2.3 (2.6) | .93 |
| MMSE | 19.6 (5.5) | 18.2 (7.7) | 19.7 (6.0) | 23.6 (1.4) | 26.1 (2.2) | .005 |
| FAQ | 10.5 (8.5) | 17.1 (10.1) | 16.6 (13.9) | 8.1 (9.9) | 12.1 (9.9) | .001 |
| NPI | 7.7 (5.7) | 11.6 (5.7) | 11.4 (5.6) | 10.5 (9.1) | 6.9 (4.5) | .002 |
| UPDRS III | 6.8 (8.6) | 32.7 (22.1) | 30.5 (27.8) | 6.7 (6.4) | 4.5 (7.7) | <.001 |
| LBCRS total score | 2.4 (1.3) | 6.1 (2.0) | 4.0 (2.9)∗ | 2.4 (0.9) | 3.0 (1.9) | <.001 |
| Bradykinesia, % | 54.0 | 97.6 | 66.7 | 75.0 | 66.7 | <.001 |
| Rigidity, % | 5.7 | 70.7 | 0.0 | 0.0 | 50.0 | <.001 |
| Postural instability, % | 21.8 | 70.7 | 0.0 | 12.5 | 33.3 | <.001 |
| Rest tremor, % | 9.2 | 36.6 | 0.0 | 0.0 | 16.7 | .002 |
| Daytime sleepiness, % | 60.9 | 92.7 | 33.3 | 50.0 | 83.3 | .002 |
| Illogical thoughts, % | 48.3 | 72.5 | 66.7 | 37.5 | 50.0 | .101 |
| Staring spells, % | 23.0 | 55.5 | 33.3 | 50.0 | 33.3 | .009 |
| Hallucinations, % | 9.2 | 53.7 | 0.0 | 0.0 | 16.7 | <.001 |
| RBD, % | 4.6 | 41.5 | 0.0 | 0.0 | 0.0 | <.001 |
| Autonomic insufficiency, % | 1.2 | 25.0 | 0.0 | 0.0 | 0.0 | <.001 |
Abbreviations: LBCRS, Lewy body composite risk score; AD, Alzheimer's disease; VaD, vascular dementia; FTD, frontotemporal degeneration; CDR, clinical dementia rating; CDR-SB, clinical dementia rating and its sum of boxes; MMSE, mini mental state examination; FAQ, functional activities questionnaire; UPDRS, unified Parkinson disease rating scale; RBD, rapid eye movement sleep behavior disorder.
∗
Two patients had vascular parkinsonism with negative dopamine transporter SPECT (DAT) scans.