Figure 3.

Reexposure to the morphine conditioning context increases AMPA GluR1 cell-surface in the NAc shell. (A–C) Using bis (sulfosuccinimidyl) suberate (BS³) surface receptor cross-linking assays, we analyze protein levels on the cell surface of GluR1, GluR2, and GluR3 in the NAc shell of morphine-conditioned rats. Through those bonds, BS³ cross-links GluRs to form high-molecular weight aggregates. Data are expressed as the means ± standard error of the mean, n = 5. *p < 0.01, compared to the morphine-conditioned group without retrieval. KD, kilodalton.