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. 2015 Apr 15;18(9):pyv030. doi: 10.1093/ijnp/pyv030

Figure 5.

Figure 5.

Effects of intra-NAc shell injection of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) AS or CS on the reconsolidation of morphine-induced conditioned place preference (CPP) and GluR1 protein expression on the cell surface. (A) Diagram outlining the behavioral procedures. (B) NAc shell Arc/Arg3.1 AS injections decreased the CPP score from the post T1 and post T2 to the priming T. Data are expressed as the means ± standard error of the mean (SEM), n = 8~10. ***p < 0.001, compared to the morphine-conditioned group microinfused with CS. (C and D) NAc shell Arc/Arg3.1 AS injections decreased the Arc/Arg3.1 protein and GluR1 protein on the cell surface that were induced by retrieval of morphine-induced CPP. Data are expressed as the means ± SEM, n = 7–9. *p < 0.05, **p < 0.01, compared to the saline conditioned group; # p < 0.05, ## p < 0.01, compared to the morphine conditioned group injection with CS. AS, antisense ODN; CS, scrambled ODN; KD; mor, morphine conditioning; post-T1, post test 1; post-T2, post test 2; priming-T, priming test; sal, saline conditioning.