Table 2.

Differences of Functional Connectivity of the Thalamus Hub Network (Analysis 1) during and after Ketamine Infusion

Time	Anatomical Region (Anatomical Labeling Atlas)	MNI Coordinates			Statistic
		x	y	z	T-value
2.5–5 min	Calcarine L	-16	-80	4	-5.19
5–7.5 min	Anterior cingulate cortex L	-12	30	26	-5.16
	Gyrus postcentralis L	-48	-24	44	4.61
	Gyrus postcentralis R	64	-14	30	5.04
	Middle temporal gyrus L	-58	-14	0	5.36
7.5–10 min	Inferior occipital gyrus R	40	-86	-8	4.74
	Gyrus precentralis R	36	-14	60	5.09
	Superior temporal gyrus L	-58	-4	-6	5.55
10–12.5 min	Gyrus precentralis R	62	8	32	4.91
	Supramarginal gyrus R	64	-18	34	4.82
	Rolandic operculum R	48	4	14	4.74
	Superior temporal gyrus L	-58	-4	-4	5.71
12.5–15 min	Middle Temporal Gyrus L	-58	-14	0	4.87
	Middle Temporal Gyrus L	-56	-8	-8	5.79
15–17.5 min	Superior Temporal Pole L	-54	8	-18	4.68
	Superior Temporal Gyrus R	56	-8	0	4.75
17.5–20 min	Thalamus R	18	-16	8	-4.60
	Middle temporal pole R	56	14	-22	4.85
	Gyrus precentralis R	62	4	32	4.64
20–22.5 min	Superior temporal gyrus L	-58	-6	6	6.51
	Middle temporal pole R	54	10	-18	4.74
22.5–25 min	Middle temporal gyrus L	-56	-14	-2	4.61
	Superior temporal pole R	52	8	-12	5.19
25–27.5 min	Superior temporal gyrus L	-62	-2	-6	5.00
	Middle temporal gyrus L	-64	-28	4	4.96
	Rolandic operculum R	52	6	12	4.91
	Insula L	-40	-2	2	4.87
	Insula R	38	2	6	4.85
	Rolandic operculum L	-52	-16	16	4.74
	Medial temporal pole R	58	10	-20	4.76
27.5–30 min	Middle temporal gyrus R	46	-40	4	5.11
30–32.5 min	Supplementary motor area L	-8	0	56	4.92
	Middle temporal gyrus L	-58	-6	-6	5.48
35–37.5 min	Thalamus L	-10	-20	8	-4.84

Time points refer to the start of the ketamine application. All values are family wise error rate (FWE)-corrected at P<.05 voxel-level.