Table 3.
Ketamine-Induced Difference of Cortico-Thalamic Connections (Analysis 2)
| Cortico-Thalamic Connectivity | |||||
|---|---|---|---|---|---|
| Time, min | Anatomical Region (Oxford thalamic connectivity atlas) | MNI coordinates | Statistics | ||
| x | y | z | T | ||
| Somatosensory cortex seed | |||||
| 2.5–5 | Ventral lateral nucleus | -10 | -12 | 4 | 4.00 |
| 5–7.5 | Ventral anterior nucleus | 10 | -4 | 4 | 4.11 |
| Pulvinar | 18 | -24 | 12 | 4.06 | |
| Medial dorsal nucleus | 4 | -16 | 10 | 3.58 | |
| 7.5–10 | Ventral anterior nucleus | -12 | -4 | 6 | 4.58 |
| Pulvinar | 20 | -26 | 14 | 4.21 | |
| Ventral lateral nucleus | 16 | -8 | 8 | 3.78 | |
| 10–12.5 | Ventral lateral nucleus | -12 | -8 | 10 | 3.99 |
| 12.5–15 | Ventral anterior nucleus | 12 | -4 | 6 | 3.94 |
| 15–17.5 | Ventral anterior nucleus | -12 | -6 | 10 | 3.75 |
| Ventral lateral nucleus | 14 | -10 | 0 | 3.50 | |
| 17.5–20 | Ventral anterior nucleus | -14 | -6 | 8 | 3.84 |
| 20–22.5 | Ventral lateral nucleus | 10 | -6 | 2 | 3.66 |
| 22.5–25 | Ventral anterior nucleus | -10 | -6 | 8 | 4.57 |
| Ventral lateral nucleus | -16 | -16 | 18 | 3.72 | |
| 25–27.5 | --- | -- | -- | -- | -- |
| 30–32.5 | Medial dorsal nucleus | -10 | -20 | 6 | 4.69 |
| Ventral anterior nucleus | -10 | -6 | 6 | 4.04 | |
| Ventral lateral nucleus | -14 | -10 | 14 | 3.79 | |
| 32.5–35 | Pulvinar | -8 | -30 | 4 | 3.61 |
| 35–37.5 | Ventral anterior nucleus | -10 | -6 | 10 | 3.89 |
| Medial dorsal nucleus | 6 | -14 | 10 | 3.52 | |
| 37.5–40 | Ventral anterior nucleus | -10 | -6 | 8 | 3.95 |
| Medial dorsal nucleus | -10 | -20 | 6 | 3.77 | |
| Temporal gyrus seed | |||||
| 2.5–5 | Medial dorsal nucleus | 2 | -18 | 8 | 3.64 |
| Ventral anterior nucleus | 8 | -8 | 12 | 4.37 | |
| Ventral lateral nucleus | -14 | -14 | 14 | 4.36 | |
| 5–7.5 | Ventral lateral nucleus | 16 | -14 | 14 | 4.16 |
| 7.5–10 | Ventral anterior nucleus | -10 | -6 | 8 | 3.86 |
| Medial dorsal nucleus | 8 | -18 | 4 | 3.75 | |
| 10–12.5 | Ventral lateral nucleus | -14 | -14 | 6 | 4.20 |
| 12.5–15 | Medial dorsal nucleus | 10 | -14 | 14 | 3.82 |
| Ventral anterior nucleus | 10 | -4 | 6 | 3.83 | |
| Ventral lateral nucleus | 8 | -10 | 4 | 3.45 | |
| 15–17.5 | Medial dorsal nucleus | -8 | -14 | 8 | 4.14 |
| Ventral lateral nucleus | 12 | -16 | 2 | 3.76 | |
| 17.5–20 | Medial dorsal nucleus | -8 | -12 | 10 | 3.63 |
| Ventral lateral nucleus | 20 | -16 | 12 | 4.46 | |
| 20–22.5 | Medial dorsal nucleus | -10 | -18 | 6 | 3.98 |
| 22.5–25 | Medial dorsal nucleus | 10 | -18 | 6 | 3.72 |
| Ventral lateral nucleus | -10 | -10 | 4 | 4.58 | |
| 25–27.5 | Ventral lateral nucleus | 16 | -8 | 8 | 3.90 |
| 27.5–30 | Ventral lateral nucleus | -12 | -8 | 6 | 4.16 |
| 30–32.5 | Medial dorsal nucleus | 6 | -18 | 8 | 4.34 |
Only the 2 cortical seed regions (somatosensory and temporal) are shown. Time points refer to the start of ketamine infusion. All values are family wise error rate (FWE)-corrected at P<.05 voxel-level after small volume correction for the thalamus.