TABLE 1.
Efficacy of 210 mg/kg per day of IND24 given to prion-infected wt and Tg4053 mice at various times before and after inoculation
| Inoculum | PrP Expression Level | Dosing Interventiona | Mean Incubation Period ± S.E.M. | n/n0 | Survival Index ± S.E.M. |
|---|---|---|---|---|---|
| dpi | days | ||||
| RML | wt | None | 118 ± 1b | 12/12 | 100c |
| 1 > | 204 ± 5b | 12/12 | 173 ± 4 | ||
| 34 > | 202 ± 2 | 12/12 | 171 ± 2 | ||
| 46 > | 197 ± 1 | 6/6 | 167 ± 2 | ||
| 60 > | 211 ± 1b | 6/6 | 179 ± 1 | ||
| 61 > | 221 ± 1 | 12/12 | 187 ± 2 | ||
| 74 > | 192 ± 14 | 5/5 | 163 ± 12 | ||
| 75 > | 162 ± 3 | 6/6 | 137 ± 3 | ||
| 77 > | 208 ± 13 | 9/9 | 176 ± 11 | ||
| 90 > | 118 ± 6 | 12/12 | 100 ± 5 | ||
| 1–61, 124–187, 243 > | 239 ± 7 | 8/8 | 203 ± 6 | ||
| 61–124 | 163 ± 6 | 7/7 | 138 ± 5 | ||
| −14 > | 452 ± 18 | 7/7 | 383 ± 16 | ||
| ∼4× | None | 51 ± 3b | 8/8 | 100c | |
| 1 > | 112 ± 4b | 9/9 | 220 ± 14 | ||
| 15 > | 122 ± 7 | 8/8 | 239 ± 20 | ||
| 26 > | 156 ± 3 | 8/8 | 306 ± 19 | ||
| 40 > | 64 ± 11 | 5/5 | 125 ± 23 | ||
| ME7 | wt | None | 126 ± 2b | 5/5 | 100c |
| 1 > | 214 ± 4b | 9/9 | 170 ± 4 | ||
| 60 > | 158 ± 5b | 7/7 | 125 ± 5 | ||
| 22L | wt | None | 111 ± 3 | 8/8 | 100c |
| 1 > | 164 ± 1 | 8/8 | 148 ± 4 | ||
| 60 > | 126 ± 2 | 8/8 | 114 ± 4 |
n, number of ill mice; n0, number of inoculated mice.
a
Day treatment started or range; > indicates dosing continued until the end of the experiment.
b
Data previously reported (Berry et al., 2013).
c
Vehicle-treated control used to calculate survival index.