TABLE 2.
Efficacy of IND24 given at increasing doses to prion-infected mice
| Inoculum | PrP Expression Level | Dose | Dosing Interventiona | Mean Incubation Period ± S.E.M. | n/n0 | Survival Index ± S.E.M. |
|---|---|---|---|---|---|---|
| mg/kg per day | dpi | days | ||||
| RML | wt | None | None | 118 ± 1b | 12/12 | 100c |
| 1 | 1 > | 142 ± 10 | 3/3 | 120 ± 9 | ||
| 5 | 1 > | 193 ± 2 | 3/3 | 164 ± 2 | ||
| 5 | 60 > | 130 ± 5 | 9/9 | 110 ± 4 | ||
| 25 | 1 > | 221 ± 9 | 5/5 | 187 ± 8 | ||
| 50 | 1 > | 286 ± 7 | 8/8 | 242 ± 6 | ||
| ME7 | wt | None | None | 126 ± 2b | 5/5 | 100c |
| 5 | 1 > | 132 ± 3 | 6/6 | 105 ± 3 | ||
| 25 | 1 > | 148 ± 4 | 7/7 | 117 ± 4 | ||
| 50 | 1 > | 192 ± 4 | 6/6 | 152 ± 4 |
n, number of ill mice; n0, number of inoculated mice.
a
Day treatment started; > indicates dosing continued until the end of the experiment.
b
Data previously reported (Berry et al., 2013).
c
Vehicle-treated control used to calculate survival index.