TABLE 3.
Compound | EC50 | Tissue | Oral Gavage, 10 mg/kg | 3-Day Feeding | ||||
---|---|---|---|---|---|---|---|---|
Cmax | tmax | AUClast | C3day | Dose | Excipient | |||
µM | µM | hours | µM⋅h | µM | ||||
IND114338 | 0.068a | Brain | 2.5a | 2 | 10.9a | 0.15 | 25 | 0.5% CMC |
2.9 | 210 | 0.5% CMC | ||||||
13.3 | 200 | 0.125% PEG400 | ||||||
Plasma | 4.1 | 2 | 15.6a | 0.24 | 25 | 0.5% CMC | ||
3.1 | 210 | 0.5% CMC | ||||||
4.7 | 200 | 0.125% PEG400 | ||||||
IND124 | 0.124 | Brain | 2.8 | 0.25 | 3.8 | 0.005 | 200 | 0.125% PEG400 |
Plasma | 1.2 | 0.25 | 1.4 | 0.003 | 200 | 0.125% PEG400 | ||
IND125 | 0.057 | Brain | 1.1 | 4.0 | 4.3 | 49 | 200 | 0.125% PEG400 |
Plasma | 0.8 | 4.0 | 2.9 | 6.0 | 200 | 0.125% PEG400 | ||
IND126 | 0.228 | Brain | 3.6 | 4.0 | 4.3 | 0.04 | 200 | 0.125% PEG400 |
Plasma | 0.3 | 4.0 | 0.5 | 0.02 | 200 | 0.125% PEG400 | ||
IND126461 | 0.070a | Brain | 0.1a | 0.5 | 0.2a | 0.10 | 200 | 0.125% PEG400 |
Plasma | 0.1 | 4 | 0.4a | 0.20 | 200 | 0.125% PEG400 |
Data previously reported (Li et al., 2013).