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. 2015 Oct;355(1):2–12. doi: 10.1124/jpet.115.224659

TABLE 3.

Pharmacokinetic parameters of five novel 2-AMTs

Compound EC50 Tissue Oral Gavage, 10 mg/kg 3-Day Feeding
Cmax tmax AUClast C3day Dose Excipient
µM µM hours µM⋅h µM
IND114338 0.068a Brain 2.5a 2 10.9a 0.15 25 0.5% CMC
2.9 210 0.5% CMC
13.3 200 0.125% PEG400
Plasma 4.1 2 15.6a 0.24 25 0.5% CMC
3.1 210 0.5% CMC
4.7 200 0.125% PEG400
IND124 0.124 Brain 2.8 0.25 3.8 0.005 200 0.125% PEG400
Plasma 1.2 0.25 1.4 0.003 200 0.125% PEG400
IND125 0.057 Brain 1.1 4.0 4.3 49 200 0.125% PEG400
Plasma 0.8 4.0 2.9 6.0 200 0.125% PEG400
IND126 0.228 Brain 3.6 4.0 4.3 0.04 200 0.125% PEG400
Plasma 0.3 4.0 0.5 0.02 200 0.125% PEG400
IND126461 0.070a Brain 0.1a 0.5 0.2a 0.10 200 0.125% PEG400
Plasma 0.1 4 0.4a 0.20 200 0.125% PEG400
a

Data previously reported (Li et al., 2013).