TABLE 4.

Efficacy of four novel 2-AMTs in scrapie and CJD prion-infected mice

Mouse Line (PrP Sequence)	PrP Expression Level	Inoculum	Treatment	Dose	Excipient	Mean Incubation Period ± S.E.M.	n/n0	Survival Index ± S.E.M.
				mg/kg per day		days
FVB (mouse)	wt	RML	None	—	0.5% CMC	115 ± 2	4/4	100b
			IND114338	25	0.5% CMC	140 ± 12	4/4	122 ± 11
				200	0.5% CMC	227 ± 19	4/4	197 ± 17
			None	—	1.25% PEG400	118 ± 1a	12/12	100b
			IND24	210	1.25% PEG400	204 ± 5a	12/12	173 ± 4
			IND125	200	0.125% PEG400	188 ± 4	8/8	159 ± 4
Tg4053 (mouse)	∼4×	RML	None	—	0.125% PEG400	51 ± 3a	8/8	100b
			IND24	210	0.125% PEG400	112 ± 4a	9/9	220 ± 14
			IND125	200	0.125% PEG400	154 ± 5	7/7	302 ± 20
			IND126	200	0.125% PEG400	61 ± 3	6/6	120 ± 9
			IND126461	200	0.125% PEG400	68 ± 3	6/6	133 ± 10
			Anle138b	200	0.125% PEG400	125 ± 4	5/5	245 ± 16
Tg1014 (chimeric human/ mouse)	∼4×	sCJD(MM1) Preparation A	None	—	0.125% PEG400	78 ± 1a	7/7	100b
			IND114338	200	0.125% PEG400	76 ± 2	8/8	97 ± 3
			IND125	200	0.125% PEG400	78 ± 3	7/7	100 ± 4
			IND126461	200	0.125% PEG400	78 ± 3	7/7	100 ± 4
			Anle138b	200	0.125% PEG400	76 ± 1	6/6	97 ± 2
		sCJD(MM1) Preparation B	None	—	0.125% PEG400	91 ± 1	8/8	100b
			IND126	200	0.125% PEG400	86 ± 1	8/8	95 ± 2

n, number of ill mice; n₀, number of inoculated mice.

^aData previously reported (Berry et al., 2013).

^bVehicle-treated control used to calculate survival index.