Table 1.

Replicated SNPs associated with late radiotherapy toxicity.

SNP	MAF	Location	Nearest Gene(s)	Cancer Site	Toxicity Endpoint	Study Type	Ref.
rs2868370	0.26	promoter	HSPB1	Lung Lung	Esophagitis Pneumonitis	Candidate Gene	13 14
rs1800469	0.31	promoter	TGFB1	Lung	Esophagitis	Candidate Gene	11
rs1800629	0.14	promoter	TNF-α	Breast	Overall toxicity	Candidate Gene	15
rs1139793	0.28	exonic (missense)	TXNRD2	Breast	Fibrosis	Candidate Gene	9
rs7120482	0.30	intergenic	MTNR1B, SLC36A4	Prostate	Rectal bleeding	GWAS	12
rs264663	0.02	intronic	TANC1	Prostate	Overall toxicity	GWAS	10