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. 2015 Sep 18;6:8303. doi: 10.1038/ncomms9303

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(a) Coomassie blue staining shows that equal amounts of lysates from Schwann cell bodies or pseudopods were separated on SDS/PAGE and used for proteomic studies. (b) Interaction network generated by the Ingenuity IPA software of proteins enriched in Schwann cell's pseudopod (Ps/CB ratio>1.25) after induction by neuronal membranes (Ps induced by neurons/Ps non induced >1). The signalling network consists of 95 proteins that are described in Supplementary Data 2. Proteins are named by their official gene symbol according to Entrez Gene (www.ncbi.nlm.nih.gov). The relative protein enrichment in pseudopods versus cell bodies (Ps/CB ratio) is colour coded according to the colour scale at the top of the figure. Proteins that were also enriched in pseudopods by serum and growth factors (Supplementary Data 3) have been given in grey. The references supporting the protein–protein interactions are listed in Supplementary Data 6. (c) Distribution of the number of Schwann cell proteins that were enriched in pseudopods based on the Ps/CB ratio. (d) Distribution of the number of proteins enriched by neuronal membranes specifically, based on the Ps induced by neurons/Ps non-induced ratio (second enrichment criteria). (e) Protein ontology analysis of the pathways most enriched in Schwann cells pseudopods (10 out of 162 shown, for complete listing, see Supplementary Data 5).