Table 2.
Results of the top all/Stage B endometriosis loci (P < 1 × 10−3) associated with WHRadjBMI at P < 0.005
| SNP | Chr | Position (B36) | RAF (allele) | Endometriosis |
Overall WHRadjBMI |
Female-limited WHRadjBMI | Nearest loci | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P-value | OR (95% CI) | P-value | Effect | SE | P-value | Effect | SE | (distance) | ||||
| All cases | ||||||||||||
| rs560584 | 1 | 168 357 136 | 0.41 (T) | 1.4 × 10−4 | 1.14 (1.07–1.22) | 1.4 × 10−5 | −0.021 | 0.005 | 1.1 × 10−3 | −0.022 | 0.677 | KIFAP3 (46 632) |
| rs12700667 | 7 | 25 868 164 | 0.74 (A) | 5.1 × 10−7 | 1.22 (1.13–1.32) | 4.4 × 10−5 | −0.023 | 0.005 | 3.4 × 10−4 | −0.028 | 0.284 | NFE2L3 (2 90 221) |
| rs2921188 | 3 | 12 387 115 | 0.64 (A) | 5.9 × 10−4 | 1.13 (1.05–1.21) | 1.1 × 10−3 | 0.017 | 0.005 | 1.8 × 10−4 | 0.026 | 0.054 | PPARG (0) |
| rs1250248 | 2 | 215 995 338 | 0.27 (A) | 1.6 × 10−5 | 1.17 (1.09–1.26) | 1.0 × 10−3 | 0.018 | 0.005 | 9.9 × 10−4 | 0.025 | 0.242 | FN1 (0) |
| rs2630787 | 3 | 21 847 339 | 0.52 (C) | 9.2 × 10−4 | 1.12 (1.05–1.19) | 1.9 × 10−3 | −0.015 | 0.004 | 0.38 | −0.006 | 0.030 | ZNF659 (79 518) |
| rs1430788 | 2 | 67 721 916 | 0.31 (C) | 9.3 × 10−5 | 1.15 (1.07–1.23) | 2.7 × 10−3 | 0.016 | 0.005 | 3.1 × 10−3 | 0.022 | 0.330 | ETAA1 (230 878) |
| rs906721 | 3 | 184 687 691 | 0.41 (A) | 6.1 × 10−5 | 1.16 (1.08–1.24) | 4.2 × 10−3 | 0.015 | 0.005 | 1.7 × 10−3 | 0.023 | 0.140 | KLHL6 (322) |
| rs1868894 | 4 | 187 606 728 | 0.80 (C) | 2.3 × 10−4 | 1.16 (1.07–1.26) | 4.9 × 10−3 | −0.018 | 0.006 | 0.13 | −0.013 | 0.524 | MTNR1A (85 075) |
| rs3820282 | 1 | 22 340 802 | 0.16 (T) | 3.3 × 10−7 | 1.26 (1.15–1.37) | 5.0 × 10−3 | −0.019 | 0.007 | 0.09 | −0.016 | 0.749 | WNT4 (0) |
| Stage B cases | ||||||||||||
| rs11619804 | 13 | 49 888 131 | 0.53 (C) | 4.8 × 10−4 | 1.17 (1.07–1.28) | 1.1 × 10−5 | 0.022 | 0.005 | 2.2 × 10−2 | 0.016 | 0.022 | CAB39L (0) |
| rs12700667 | 7 | 25 868 164 | 0.74 (A) | 3.3 × 10−9 | 1.36 (1.23–1.50) | 4.4 × 10−5 | −0.023 | 0.005 | 3.4 × 10−4 | −0.028 | 0.284 | NFE2L3 (290 221) |
| rs2782659 | 6 | 45 794 768 | 0.33 (G) | 4.2 × 10−4 | 1.18 (1.08–1.30) | 9.2 × 10−5 | 0.020 | 0.005 | 1.7 × 10−4 | 0.027 | 0.108 | RUNX2 (167 970) |
| rs6556301 | 5 | 176 460 183 | 0.63 (G) | 7.4 × 10−4 | 1.17 (1.07–1.28) | 1.9 × 10−4 | −0.021 | 0.005 | 7.8 × 10−3 | −0.021 | 0.845 | FGFR4 (2450) |
| rs1250248 | 2 | 215 995 338 | 0.27 (A) | 2.9 × 10−8 | 1.32 (1.19–1.45) | 1.2 × 10−3 | 0.018 | 0.005 | 9.9 × 10−4 | 0.025 | 0.242 | FN1 (0) |
| rs4131816 | 1 | 161 662 648 | 0.85 (T) | 5.4 × 10−4 | 1.24 (1.10–1.41) | 1.5 × 10−3 | 0.022 | 0.007 | 0.25 | 0.011 | 0.072 | NUF2 (70 470) |
| rs9912335 | 17 | 77 552 948 | 0.69 (T) | 3.1 × 10−4 | 1.19 (1.08–1.31) | 3.5 × 10−3 | −0.021 | 0.007 | 0.10 | −0.016 | 0.454 | ASPSCR1 (0) |
| rs10878362 | 12 | 64 703 760 | 0.69 (C) | 4.9 × 10−4 | 1.19 (1.08–1.31) | 3.6 × 10−3 | 0.015 | 0.005 | 3.1 × 10−3 | 0.022 | 0.204 | HMGA2 (57 421) |
| rs2807357 | 1 | 22 364 571 | 0.64 (A) | 9.7 × 10−4 | 1.16 (1.06–1.27) | 3.7 × 10−3 | −0.015 | 0.005 | 1.0 × 10−3 | −0.024 | 0.081 | WNT4 (22 373) |
| rs906721 | 3 | 184 687 691 | 0.41 (A) | 1.4 × 10−4 | 1.20 (1.09–1.32) | 4.2 × 10−3 | 0.015 | 0.005 | 1.7 × 10−3 | 0.023 | 0.140 | KLHL6 (322) |
| rs12267660 | 10 | 4 419 530 | 0.85 (G) | 7.9 × 10−4 | 1.24 (1.09–1.40) | 4.6 × 10−3 | 0.02 | 0.007 | 8.0 × 10−3 | 0.030 | 0.133 | CR749391 (191 913) |
| rs11685481 | 2 | 67 590 253 | 0.15 (C) | 8.4 × 10−4 | 1.23 (1.09–1.38) | 4.8 × 10−3 | 0.018 | 0.006 | 1.1 × 10−2 | 0.022 | 0.451 | ETAA1 (99 215) |