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. 2015 Sep 14;210(6):991–1002. doi: 10.1083/jcb.201502029

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© 2015 Zhou et al.

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Figure 9. — PSAP regulates PGRN trafficking in vivo. (A) PGRN and PSAP colocalize with LAMP1 in cortical neurons of the adult mouse brain. (B) Both sortilin and PSAP are expressed in cortical neurons of the adult mouse brain. (C) Enlarged lysosomes and PGRN mislocalization in cortical neurons of PSAP^−/− mice. PSAP^−/− and littermate wild-type mice were sacrificed at postnatal day 21 and 15-µm brain sections were stained as indicated. Bars: (main) 20 µm; (inset) 5 μm. (D) Quantification of PGRN signals inside LAMP1-positive vesicles in C using ImageJ. Data are given as mean ± SEM from three pairs of mice: *, P < 0.05, Student’s t test. (E) Serum PGRN levels in newborn wild-type, PSAP^+/−, and PSAP^−/− littermate mice before the appearance of any apparent lysosomal phenotype in PSAP^−/− mice. Data are given as mean ± SEM from four groups of mice. **, P < 0.01; ***, P < 0.001, one-way analysis of variance.