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. 2015 Sep 14;210(6):899–916. doi: 10.1083/jcb.201506020

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© 2015 Wynne and Funabiki

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Figure 4. — Formation of the expanded kinetochore requires outer kinetochore proteins and CENP-C. (A) Model of kinetochore expansion. Proteins present on the expanded kinetochore are shown in magenta, whereas the core kinetochore proteins are in green. Question marks indicate sites of potential oligomerization. (B–G) Mitotic chromosomes assembled in Xenopus egg extracts after depletion indicated, treated with nocodazole, and stained for the kinetochore proteins indicated. Bars, 1 µm. (C, E, and G) Quantification of total signal from chromosome clusters in extracts from B, D, and F. P-values from Mann–Whitney test and percentage of mean value relative to ΔIgG are indicated above each condition. Mean and standard deviation are plotted in black. All images are maximum intensity projections of 3D-SIM datasets.