Table 2.
Characteristic | Vosaroxin schedule |
Total (n = 73) |
||||
---|---|---|---|---|---|---|
Weekly (n = 42) |
Twice weekly (n = 31) |
No. | % | |||
No. | % | No. | % | |||
Age, years | ||||||
Median | 65 | 65 | 65 | |||
Range | 21–81 | 26–85 | 21–85 | |||
Sex | ||||||
Male | 27 | 64 | 18 | 58 | 45 | 62 |
Female | 15 | 36 | 13 | 42 | 28 | 38 |
Race or ethnicity | ||||||
Asian | 1 | 2 | 1 | 3 | 2 | 3 |
Black or African American | 6 | 14 | 3 | 10 | 9 | 12 |
Hispanic or Latino | 4 | 10 | 5 | 16 | 9 | 12 |
White | 31 | 74 | 22 | 71 | 53 | 73 |
ECOG performance status | ||||||
0–1 | 38 | 90 | 30 | 97 | 68 | 93 |
2 | 4 | 10 | 1 | 3 | 5 | 7 |
Diagnosis | ||||||
AML | 35 | 83 | 27 | 87 | 62 | 85 |
ALL | 4 | 10 | 4 | 13 | 8 | 11 |
MDS transformed to AML | 3 | 7 | 0 | 0 | 3 | 4 |
Disease status | ||||||
Relapsed | 7 | 17 | 7 | 23 | 14 | 19 |
Refractorya | 34 | 81 | 23 | 74 | 57 | 78 |
Others | 1 | 2 | 1 | 3 | 2 | 3 |
No. of prior chemotherapy regimens | ||||||
0–3 | 24 | 57 | 15 | 48 | 39 | 53 |
4–9 | 18 | 43 | 16 | 52 | 34 | 47 |
Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; ECOG, Eastern Cooperative Oncology Group; MDS, myelodysplastic syndrome.
Defined as not achieving complete remission after most recent prior leukemia therapy.