Table 5.
Schedule dose group |
Age (years) |
Disease status |
Cytogenetic risk categorya |
Cytogenetics at baseline |
Cytogenetics at response | IWG response |
Duration of response (months) |
---|---|---|---|---|---|---|---|
Weekly | |||||||
50 mg/m2 | 66 | First relapse | Intermediate | 46,XY | 46,XY | CRp | 2.4 |
72 mg/m2 | 41 | Refractory | Unfavorable | 47,XY, 9qht, t(11;19)(q23;p13.1),+21 | Not done | CRp | 3.1 |
72 mg/m2 | 40 | Refractory | Not done | Not done | Not done | CR | 1.7 |
90 mg/m2 | 71 | Primary refractory | Unfavorable | 46,XX, der(7)t;(5;7) (p13,p11.2) | 46,XX | CR (CRc) | 9.1 |
Twice weekly | |||||||
40 mg/m2 | 73 | Refractory | Intermediate | 46,XX | 46,XX | CR | 19.2 |
Abbreviations: CR, complete response; CRc, cytogenetic complete response; CRp, complete response with incomplete recovery of platelets (<100 × 109/l); IWG, International Working Group.
Southwest Oncology Group classification.