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PRL stimulates kinase activity of PAK1 and PAK1 ability to form protein–protein interaction. PRL binding induces dimerization of the PRLR and subsequent activation of JAK2. JAK2 phosphorylates PAK1 on three tyrosines, Tyr 153, 201 and 285. Tyrosyl phosphorylation of PAK1 enhances both a Rac-dependent (Rider et al. 2013) and Rac-independent PAK1 kinase activity (Hammer et al. 2013), and also the ability for PAK1 to act as a molecular scaffold (Hammer et al., unpublished)
