Skip to main content
. Author manuscript; available in PMC: 2015 Sep 21.
Published in final edited form as: Adv Exp Med Biol. 2015;846:97–137. doi: 10.1007/978-3-319-12114-7_5

Fig. 5.7.

Fig. 5.7

Tyrosyl phosphorylated PAK1 regulates cell motility in response to PRL through filamin A. PRL-activated JAK2 tyrosyl phosphorylates PAK1 increasing PAK1 kinase activity and scaffolding ability of PAK1. pTyr-PAK1 has increased FlnA interaction and phosphorylates FlnA on Ser2152. FlnA activates PAK1 in a positive feedback loop. JAK2 also phosphorylates SH2B1β, which binds to FlnA and cross-links actin filaments. Positive feedback from FlnA to PAK1 and SH2B1β to JAK2 facilitates the formation of more JAK2/SH2B1β/FlnA/pTyr-PAK1 complexes that regulate actin remodeling during enhanced cell motility in response to PRL