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. Author manuscript; available in PMC: 2015 Sep 21.
Published in final edited form as: Adv Exp Med Biol. 2015;846:97–137. doi: 10.1007/978-3-319-12114-7_5

Fig. 5.8.

Fig. 5.8

GIT1/βPIX/PAK1/paxillin complex. PAK1 binds to the N-terminal SH3-domain of βPIX. βPIX has a DBL-homology (DH) domain and a plextrin homology (PH) domain, and binds to GIT1 through a C-terminal GIT1-binding domain. GIT1 has a C-terminal paxillin-binding domain (PAX) that binds to the LD4 domain of paxillin and SHD domain that binds to βPIX. PAK1 can phosphorylate Ser273 of paxillin at adhesion complexes