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. Author manuscript; available in PMC: 2015 Sep 21.
Published in final edited form as: Adv Exp Med Biol. 2015;846:97–137. doi: 10.1007/978-3-319-12114-7_5

Fig. 5.9.

Fig. 5.9

PRL-dependent tyrosyl phosphorylation of PAK1 regulates adhesion turnover. PRL-activated JAK2 phosphorylates PAK1 at Tyr285 and stimulates both PAK1 activities: kinase activity and ability of PAK1 to form the GIT1/βPIX/pTyr285 PAK1 complex. This complex localizes to small adhesion complexes, the amount of which is increased by PRL treatment. Increased GIT1/βPIX/pTyr-285PAK1 association leads to enhanced phosphorylation of paxillin on Ser 273 that results in enhanced adhesion turnover and finally to increased cell motility