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Hypothesized TGFβ1 homeostatic feedback mechanism occurring within the proton-irradiated adolescent (AP) hosts. All genes, functions or interactions that are upregulated are color-coded red, while all functions or interactions which are downregulated or inhibitory are color-coded blue. The hypothesized interactions in the spleen are denoted by a red dotted line. The gray dotted line represents the hypothesized interaction between the spleen and the tumor.
