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. 2015 Apr 2;212(8):1270–1278. doi: 10.1093/infdis/jiv210

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© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

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Figure 3. — HA1-specific antibody (Ab) binding affinity following H7N7 inactivated influenza vaccination is enhanced by H7N7 live attenuated influenza vaccine (LAIV) priming. Off-rate constants are shown for polyclonal serum Ab binding to the H7 HA1 (A) and HA2 (B) proteins of influenza H7N7 NL/03. Sera were collected from H7N7 LAIV–primed (circles), H2N3 LAIV–primed (triangles), and unprimed (diamonds) cohorts at the time of inactivated vaccine administration (day 0; open symbols) and after 14 days (filled symbols). Ab off-rate constants, shown for individual subjects, were determined by surface plasmon resonance and provide a measure of net binding affinity. Differences were examined by paired t tests (for within-cohort comparisons) and 2-sample t tests (for between-cohort comparisons), using data on a log scale. P values are shown for all within-cohort comparisons and for between-cohort comparisons that were significantly different (P < .05). Abbreviation: HA, hemagglutinin.